Omics
Microbial Genome Similarity Search with FASTQ (MGSS-FASTQ)
Project goal: Develop a tool to enable rapid identification of microorganism genomes from raw sequencing data generated by NGS/MPS and stored in FASTQ files, leveraging the RefSeqMasher algorithm but extending searches across the entire GenBank database, and providing online access through an intuitive web interface for query management. Show more
Chemistry
De novo Design and Synthesis of Selective Inhibitors for Carbonic Anhydrase Isoforms II, IX and XII
Project goal: Establish a de novo, structure-based workflow to design and synthesize small-molecule inhibitors selective for carbonic anhydrase isoforms II, IX, and XII, achieving nanomolar binding affinity and a novel mechanism distinct from known references. Show more
De novo Design of Dual mTOR/EGFR Inhibitor for a Double-Punch Effect
Project goal: Develop a single small molecule capable of selectively inhibiting both mTOR (serine-threonine kinase) and EGFR (tyrosine kinase) by identifying a shared structural motif that engages distinct active-site interactions, achieving a dual-target effect. Show more
Hybrid Chemical–Bioconjugation Polypeptide Synthesis (Semaglutide)
Project goal: Validate a streamlined hybrid route to produce semaglutide suitable for pilot‐scale manufacturing, using microwave‐assisted SPPS and site‐selective bioconjugation. Show more
Multifunctional Agents Targeting Microtubules
Project goal: A concise in silico workflow was used to design, synthesize, and validate small molecules that disrupt microtubule dynamics, induce G2/M cell cycle arrest, and demonstrate enhanced efficacy in vitro and in vivo compared to osimertinib in a zebrafish GBM model. Show more